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Progesterone and Fertility

Fertility & Progesterone

Progesterone is recognized as a vital female hormone central to successful conception and a healthy pregnancy. The word "progesterone" is itself etymologically related to the Latin root gestare - meaning to bear or carry - suggesting the importance of this hormone in creating a fertile environment for conception and the continuing development of the embryo. (Many women report that FertilAid for Women has helped normalize their progesterone levels. Additionally, many women indicate that external adminstration of a natural progesterone cream such as FertileBalance can be beneficial.)

In short, progesterone is a female sex hormone that is secreted by the corpus luteum to prepare the endometrium for implantation of the fertilized egg. Following implantation off the egg, the developing placenta signals the body to produce progesterone and prevent rejection of the developing embryo or fetus. Without this continuuing progesterone production, the endometrium would shed and menstruation would ensue. Therefore, progesterone plays a significant role in reproduction. Thus, progesterone...

  • Helps create a fertile, warm environment in the womb and promotes the survival of the fertilized egg through healthy implantation.
  • Strengthens and maintains the secretory endometrium which sustains the embryo throughout pregnancy.
  • Prevents the premature shedding of the secretory endometrium (menstruation).

As progesterone forestalls the shedding of the endometrium (where embryo implantation occurs), low progesterone levels - or a significant drop in progesterone levels - during the first few weeks of pregnancy may correspond with miscarriage.

Here, progesterone plays a 'secretory’ role in the reproductive organs. It stimulates changes in the uterus and supports pregnancy by increasing blood vessel and tissue development in the endometrium.

Progesterone, Fertility, and Reproduction

During a woman's cycle, progesterone levels rise rapidly at ovulation to provide a fertile environment for the fertilized egg. Here, progesterone is also responsible for the increase in body temperature at ovulation that lasts through most of the luteal phase. Beginning with ovulation, the corpus luteum produces progesterone for several days (and the concomitant temperature increase is in most cases easily measurable through methods of BBT/fertility charting).

If fertilization and implantation take place, the placenta takes over the role signalling progesterone production and in further maintaining a supportive environment for embryonic and fetal development. If fertilization does not occur, progesterone levels fall dramatically (usually after 10-12 days) triggering the shedding of the secretory endometrium (menses).

Because progesterone is essential in preventing the shedding of the secretory endometrium, a significant drop in progesterone levels during the first 10 - 12 weeks of pregnancy may result in a miscarriage.

Addressing the Issue of Low Progesterone Levels

Low progesterone can be detected by a blood test after ovulation or by charting fertility. Another sign of low progesterone is a shortened luteal phase that lasts less than 10 days.

There are several things you can do to boost deficient progesterone levels. Clearly, visiting a doctor to discuss the nuances of a particular issue may be the best first option. However, a fertility supplement, like FertilAid for Women, may help to bring progesterone levels into an ideal range for achieving pregnancy.

Women with a history of miscarriage can also use natural progesterone cream as soon as they know they have ovulated, to supplement their own progesterone; however, natural progesterone creams should not be used until ovulation takes place. Consult your physician for more information on the benefits of progesterone and uses/applications.

Other Applications of Progesterone

Progesterone has many other functions, among them protecting against fibrocysts, helping the body use fat for energy, and helping normalize blood clotting and blood sugar levels. Today, many health professionals claim that the symptoms associated with PMS and menopause are due not so much to estrogen, but to a deficiency of progesterone and an overabundance of estrogen. It is believed that progesterone balances estrogen and that an overproduction of estrogen can lead to health problems. However, consult your physician if you have any questions about using natural progesterone creams.

> Back to Preconception
> Ovulatory Dysfunction and Hormonal Balance
> Anovulation
> Short Cylces Why are short menstrual cycles a possible TTC issue?


Hi i learnt yesterday that my Progesterone levels are low 3.8 by my GP. i was shocked to say the least! with this shock i didnt ask the question I now know i should have. My GP told me it could be early menapause? im 33 how can this be?
im devastated and i hate it - not in to see teh GP unil next weds again. in the meantime i have had another blood test and im praying im not going through the menapause!!!
I cant understand any of this or why my levels have dropped... Any advice would be really appriciated. im even too scared to discuss this with my partner and know thats not right... I feel that we shoul dhave had children earlier and not focused on work work work.... i feel responsible...

I have not had a period since 2007 right before my daughter was conceived. Now we are trying for our second child and have had no luck, my progesterone level was 0.3 and I was started on prometrium 200 mg daily, still no period, wonder if thus will get better??

I have not had a period since 2007 right before my daughter was conceived. Now we are trying for our second child and have had no luck, my progesterone level was 0.3 and I was started on prometrium 200 mg daily, still no period, wonder if thus will get better??

I have PCOS(polycystic ovary syndrome)and have irregular cycles.Its almost a year we are trying for pregnancy .iam in second round of clomid tablets(100mg)from day 5th-day 9th after my period,and from day 9 onwards prometrium tablets(1 tablet.daily),in addition with this im taking metformin tablets daily(3 tablets per day).After 21 days from my period,ill be taken progesterone blood work.Now in the second month(2nd round)of my clomid medication,my progesterone blood test result is 59.8ng/ml and in my 1st month my progesterone was 40.3ng/ml.What does it mean?I think my progesterone is getting increased after the high dose of clomid..but what will be progesterone level to bet pregnant..How long my level should increase from 59.8ng/ml?Does anyone know..pls advice me and comment on my post..Hoping for replies!!!

DO NOT take progesterone suppliments of any kind until you have positively ovulated. Progesterone acts as a natural birth control and can kill the egg before it has a chance to fertilize. I was prescribed progesterone and directed to take it at day 14 as a treatment for 2 previous miscarriages w/in 6 months. After taking the progesterone for 10 months, nothing happened. After seeking a second opinion, I was told about progesterone's potential for killing the egg. I was advised to take an ovulation test and begin taking the progesterone 3 days after ovulation - 2 months later, I am now entering my second trimester!

if progesterone level is only 16, will it consider enough ovulated to prepare for prenant?

I have been taking progesterone 20mg from day 16 to 26 for the last 4 years due to severe pmt and it has really helped. I have been with my husband three and a half years and have not fallen pregnant. My Dr advised me to stop taking the progestrone as a first step, but from reading the above I can see that Progestrone is a help and not a hindrence in conception. Please advise what to do as i am 41 now and would like to conceive soon.

Thank you

my husband and i are ttc..we have had 2 early miscarriages. so i have been on 50 mg of clomid for the last 6 months and 500 mg of glucophage daily. taking clomid on d5 thru d9 of cycle and just had my progesterone level drawn on d 21. my level was over 20 and all my doc said was if i didn't start my cycle on day 28 to call her and schedule an appointment. Is this a good level?

hello gals, two months ago i had a miscarriage after then i could not get a normal period the first period i had lasted three days and was very light, this month i started the month off with brown discharge for 3 weeks i had alot of weird things happenng , my breast would pain , i had insomnia,i was anxsious i was bloated i would forget where i dropped things and one day there was red blood just enough to wipe. the week after that i had started my period and it rushed with alot of clotts. what could this be do you think it could be low progesterone.

I am on my second round of clomid and I just got my progesterone level back. It was 75 which is tons better than the first round (0.05). This was achieved by increasing the Clomid dose from 50 to 100 mg. I was happy that this means I ovulated, but I was also getting excited I could possibly be pregnant. But today I started my period. I usually start late, but this is day 21 since my last period. Waiting to hear back from the NP, but I am sure I will start taking the Clomid again in two days from now. Try try again! Hang in there girls and ask lots of questions from your DR and NP. I am a nurse and I know sometimes it can be overwhelming when you are a patient, but write down questions you have before the appointment so you don't forget them. Also if your MD is not giving you info or seems like their not doing enough, go to someone else. This is your body and you need to be in charge and know all of the options. Good luck to everyone and take care!

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