Could Letrozole be the Answer to Infertility?

Traditionally, doctors have prescribed Clomiphene (Clomid) for women struggling to become pregnant because of PCOS and/or irregular cycles.  Because of a recent study, there is a new drug that may soon take its place! 


Letrozole, a drug used most often to treat breast cancer in postmenopausal women is now making its way into the fertility world!

The National Institutes of Health just had their Letrozole study published in The New England Journal of Medicine.

Researchers studied a group of 750 women who were randomly chosen to either take Clomid or Letrozole as part of their fertility plan for five cycles.  What they found was that 28% of the Letrozole group became pregnant and had a healthy birth, whereas only 19% of those taking Clomid had the same outcome.

There weren’t significant differences in terms of multiple births, birth defects or miscarriages between the two groups.  This was also true when it came to the side effects for each drug.  About a third of each group reported hot flashes, fatigue and dizziness.

It will take more research before Letrozole is the go to drug for infertility.  However, it may soon be used for women who did not successfully become pregnant with Clomid. 

Any time we can add a new option to our TTC master plan, it is a good thing!



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By TTC veteran and mother of two, Elizabeth Andrews.