PCOS.......Which Drug To Take?


If you suffer from PCOS (Polycystic Ovary Syndrome) and are currently working with your doctor to decide which drug to take to help you ovulate, this study may be of interest to you!

The New England Journal of Medicine published a study that looked at the results of women who had PCOS and used either Clomiphene, Metformin, or a combination of both to help regulate their ovulation.

The study included 626 infertile women who were broken up into 3 different groups that then took either Clominphene, Metformin, or both drugs together. Afterwards, the women’s progesterone levels were tested to monitor their ovulation. Once their ovulation cycle was pinpointed, they were asked to have sex every 2-3 days. They took the drugs and continued this routine for 6 months unless they became pregnant. If pregnant, then they stopped the regiment immediately.

What the researchers found was that of the 3 groups, 60% of those who took the combination of both drugs ovulated. In comparison, 49% of women who took only Chlomiphene and 29% of women who took only Metformin ovulated. In addition, they also looked at the birthrate from the 3 groups. The results were as follows: 28.6% of women in the combination group gave birth, 22.5% of women in the Chlomiphene group, and 7.2% in the Metformin group.

As a final statement, the researchers say that based on their study, women that take Clomiphene as opposed to Metformin were 2 times more likely to ovulate.

So………….just something to talk about with your fertility doctors!

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By TTC veteran and mother of two, Elizabeth Andrews.