Could the Enzyme SGK1 Be the Answer to Infertility and Miscarriage?

Enzyme SGK1In a recent study done at the Imperial College in London, researchers looked at the connection between the enzyme SGK1 and infertility & miscarriage. 

The first part of their study involved looking at womb lining samples from 100 women who were actively trying to conceive. 

What they found out was that women who were diagnosed with unexplained infertility had high levels of the enzyme SGK1 and those who had recently experienced a miscarriage had low levels of the enzyme when compared to the womb linings of women who did not struggle with fertility issues. 

The researchers then took these results back to the lab to explore further with mice. 

Typically in women, the levels of the enzyme SGK1 start to decrease in the days leading up to ovulation.  This process seems to be an important part of the puzzle in terms of the uterus being able to hold onto and support the implanted egg.

When researchers changed this natural body rhythm by injecting the mice with additional SGK1 enzyme during the most fertile part of their cycle, they found that those mice were not able to become pregnant. In addition, when researchers completely blocked the enzyme during they same part of their cycle, there were also problems.  These mice were able to become pregnant but had a smaller numbers of babies and also exhibited bleeding, which they assumed was because of miscarriage.

So, the researchers believe that some of the SGKI enzyme is essential for a healthy pregnancy.  When there levels of this enzyme are too high or nonexistent, it can lead to infertility and miscarriage.

They are confident that there will be more studies done in this area, because the implications could change the world of fertility.  Doctors could test for the enzyme levels before women are actively trying to conceive and then treat their patients accordingly.  It is always exciting to read about new research that may make it easier for many women to become pregnant!!!!


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By TTC veteran and mother of two, Elizabeth Andrews.