Clomid: How it Works and What to Expect

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Is Clomid the Right Fertility Medication for Me? Clomid, Infertility and Ovulation Induction


Clomid (clomiphene, clomiphene citrate) is among the most well-know and frequently prescribed of all fertility drugs. Clomid is taken orally and is considered a "first line" prescription fertility drug for dealing with infertility issues. Clomid is so widely prescribed that you may even find a "Clomid Club" on many preconception forums and communities. Clomid is used predominately for inducing ovulation in women with ovulatory disorders like anovulation, PCOS, and other infertility symptoms.

Clomid works by impacting hormonal production, by influencing the "fertility hormones" (estrogen, FSH, and LH) that precipitate ovulation. Like many prescription medications, Clomid works by "tricking the brain" into believing that estrogen levels in the body are low. This in turn encourages the brain to send signals to release more Gonadotropin Releasing Hormone (GnRH), which causes the pituitary gland to produce more FSH (follicle stimulating hormone) and LH (luteinizing hormone). LH is the hormone that facilitates ovulation (the release of the egg), and it's also the hormone used as the marker in urine ovulation testing.

Sounds complicated? In effect, clomid precipitates, through these various hormonal mechanisms, increased production of LH and FSH, which in turn foster a mature ovarian follicle and the release of the ovum. This is called ovulation induction. In more clinical terms, Dr. G. Berger notes: "Structurally like estrogen, clomiphene binds to the sites in the brain where estrogen normally attaches, called estrogen receptors. Once these receptor sites are filled up with clomiphene, they can't bind with natural estrogen circulating in the blood and they are fooled into thinking that the amount of estrogen in the blood is too low. In response, the hypothalamus releases more GnRH, causing the pituitary to pump out more FSH, which then causes a follicle to grow to produce more estrogen and start maturing an egg to prepare for ovulation".

Clomid is taken orally for about five days near the beginning of the cycle. Dosage and "start dates" will be indicated by the prescribing doctor. Once ovulation commences, most pregnancies occur in the first 6 cycles of treatment. While clomid has a high rate of success in inducing ovulation, it cannot guarantee pregnancy. Note: if you test too early for ovulation in your cycle with a urine ovulation test (lh), you may receive a false positive on an ovulation test when using clomid.

Fertility Supplements and Clomid: Currently, there are a number of herbal-nutritional supplements on the market containing vitex (chasteberry, vitex agnus castus). These products may be viewed as an herbal infertility therapy, and products like FertilAid and FertilityBlend are based on impressive clinical studies indicating that fertility can be improved with fertility supplementation. However, both of these manufacturers indicate that clomid should not be used in conjunction with vitex (or herbal infertility products in general). Fertility supplements like Fertility Blend and FertilAid are non-prescription. While on clomid, women are still encouraged to take a prenatal supplement with folic acid.

Well-known side effects of clomid include - you guessed it - multiple births (aka twins, triplets...). For women using clomid, twins may occur in 5% of births. Triplets are much less frequent. Although there has been some discussion linking prescription infertility treatments like clomid to ovarian cancer, evidence seems to point now to other causes, even infertility itself as a cause of some cancers. There is no evidence that clomid causes an increase in congenital abnormalities or birth defects in children.

Clomiphene and Clomid Abuse. While clomid cannnot be "abused" in any traditional sense, it can be prescribed (or rather over-prescribed) for infertility issues before a fertility workup has been performed, or before there is even any sign of ovulatory disorder, anovulation, luteal phase defect (LPD), PCOS, etc. Proper screening is essential prior to prescription. Given that male fertility issues constitute nearly 30% of infertility cases, a thorough evaluation and/or fertility workup should be performed on the woman to verify that ovulation induction via clomid is indeed required. For women without ovulatory/ovulation issues or infertility symptoms, clomid use may actually interfere with conception. Before accepting a clomid prescription, ensure that your doctor has performed the requisite infertility workup and/or has correctly identified a fertility issue or ovulatory disorder.

Women with liver disease should not use clomid. Clomid should not be given to patients with ovarian cysts, since they may grow larger. It should not be taken by a patient who may be pregnant, although there is no proof of fetal problems or complications.

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Comments

I found out I had PCOS when I was 17, so I knew it would be hard to get pregnant. I was put on clomid in jan. 2010 50mg got pregnant 1st round, had our little girl oct 1st 2010. Now we are trying for our second child because ive been having lots of pain from my PCOS and doctor says I am gonna have to have hysterectomy!! I started 1st round of clomid saturday go back this thursday for u/s praying we are as lucky as we were last time. I am also on 2000mg of metformin a day and I didnt take it my first pregnacy!

i guess many people don't know, but a widely known treatment for pcos and diabetes mellitus is glucophage and after being treated with this medication, I have had many of my friends get pregnant with their first child or second. You do need to be seen by either your primary or endocrinologist and always talk with your doctor before taking any new medication, even otc.

hi, i had a m/c in march in i could not ovulate.so, just last month i took my first round of clomid. well, i ovulated but didn't get pregnant. i hope this month which will be my second round on clomid it will be a success.

Hi everyone,
1st of all just want to say its nice to find a new site, all other sites i've seen have been from years ago.
I started my 1st round of 50mg clomid in July after TTC for 2 years, to my suprise it worked 1st time but sadly had a missed miscarriage, found out at my 9 week scan that there was no heartbeat & bub was only 8 weeks in size. We were gutted to say the least. My dr told me to wait for a period after having a d&c before taking clomid & trying again. I am now on my 2nd round, had the last tablet today so hopefully ovulation occurs sometime next week. Starting to feel doubtful that it will work tho, has anyone else had success with clomid after having a misscarriage? Any info would be greatly appriciated.

i havent heard bout clomid before my fiancee told me bout katie price trying it to try and conceve with her ex hubby alex reid and i am a little concerned bout the side effects after taking a certain amount of clomid and i havent tried it yet and havent ordered any from my drs yet and i am a little concerned that i may not be able to coneve as me and my fiancee have been trying for nearly 2 yrs and no luck any helpfull tips will be appreciated thanks Smile

I am 28yrs old, got married 2 yes ago, just found out that I hav pcos at 27 yes old.i don't hav menses at all for 1 ur plus before checking up with my doc, I'll only get menses with pills, and I'm diagnosed wt diabetes mellitus as well. I went to my o Ng specialist and already on 4 cycle of clomid but no success yet, the last at 150 mg. Hsg done normal but found out my husband have borderline low sperm count, not oligospermia yet. I really want to conceive a child, as all my friends and relative got married after mr already got pregnant n some even hav babies. I'm depressed. What should I do?

I have a 21 month old who was conceived after 6 rounds of clomid. The first 5 rounds I did not ovulate at all. Now we are trying for another. I have PCOS and anovulation, so trying on our own would be fruitless. My dr, fertility specialist, put me on Clomid 50mg. I went for a dr appt on day 14. They did an ultrasound and said that I did not ovulate, so they put me on another round at a higher dose, without waiting for my next cycle. Has anyone ever been prescribed Clomid like this? I am currently on day 3 of this second dosage, so I will see how it goes!

hi this is my first cycle of clomid i start taking clomid when i was in ghana , i got pregnant the first tme with clomid but m/c 6 weeks later tear . now i am scared rite now b cos of the m/c i had b 4 , but my doctor prescribe clomid again to me , but i am not sure , i am really thinkin abot artificial n semination , . but my husband so set against it the ideal , but he dont know my pain frm the m/c

I am a 21 year old newlywed, I have moderate dysplasia and it causes infertility. I am currently on my "3rd," cycle of clomid. Hopefully It works this time around. I have been so emotional throughout the process. So wish me luck ladies!

Hello everyone...I was diagnosed with endometriosis in July and had laproscopic surgery in August..I started my 1st cycle of clomid (50mg) in October didn't ovulate..my 2nd cycle in November (100mg) and my doctor called me on yesterday and told me that I did indeed ovulate this time around, so I praying that we conceived this time...if my menustral cycle doesn't start by Dec. 12 she said it's a great chance that we did conceive...I'm 34 with no kids so I'm praying because my heart's greatest joy is becoming a mother...I will keep you posted...praying that everyone is blessed in the upcoming year with a healthy bundle of joy!

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