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Clomid: How it Works and What to Expect

Is Clomid the Right Fertility Medication for Me? Clomid, Infertility and Ovulation Induction

Clomid (clomiphene, clomiphene citrate) is among the most well-know and frequently prescribed of all fertility drugs. Clomid is taken orally and is considered a "first line" prescription fertility drug for dealing with infertility issues. Clomid is so widely prescribed that you may even find a "Clomid Club" on many preconception forums and communities. Clomid is used predominately for inducing ovulation in women with ovulatory disorders like anovulation, PCOS, and other infertility symptoms.

Clomid works by impacting hormonal production, by influencing the "fertility hormones" (estrogen, FSH, and LH) that precipitate ovulation. Like many prescription medications, Clomid works by "tricking the brain" into believing that estrogen levels in the body are low. This in turn encourages the brain to send signals to release more Gonadotropin Releasing Hormone (GnRH), which causes the pituitary gland to produce more FSH (follicle stimulating hormone) and LH (luteinizing hormone). LH is the hormone that facilitates ovulation (the release of the egg), and it's also the hormone used as the marker in urine ovulation testing.

Sounds complicated? In effect, clomid precipitates, through these various hormonal mechanisms, increased production of LH and FSH, which in turn foster a mature ovarian follicle and the release of the ovum. This is called ovulation induction. In more clinical terms, Dr. G. Berger notes: "Structurally like estrogen, clomiphene binds to the sites in the brain where estrogen normally attaches, called estrogen receptors. Once these receptor sites are filled up with clomiphene, they can't bind with natural estrogen circulating in the blood and they are fooled into thinking that the amount of estrogen in the blood is too low. In response, the hypothalamus releases more GnRH, causing the pituitary to pump out more FSH, which then causes a follicle to grow to produce more estrogen and start maturing an egg to prepare for ovulation".

Clomid is taken orally for about five days near the beginning of the cycle. Dosage and "start dates" will be indicated by the prescribing doctor. Once ovulation commences, most pregnancies occur in the first 6 cycles of treatment. While clomid has a high rate of success in inducing ovulation, it cannot guarantee pregnancy. Note: if you test too early for ovulation in your cycle with a urine ovulation test (lh), you may receive a false positive on an ovulation test when using clomid.

Fertility Supplements and Clomid: Currently, there are a number of herbal-nutritional supplements on the market containing vitex (chasteberry, vitex agnus castus). These products may be viewed as an herbal infertility therapy, and products like FertilAid and FertilityBlend are based on impressive clinical studies indicating that fertility can be improved with fertility supplementation. However, both of these manufacturers indicate that clomid should not be used in conjunction with vitex (or herbal infertility products in general). Fertility supplements like Fertility Blend and FertilAid are non-prescription. While on clomid, women are still encouraged to take a prenatal supplement with folic acid.

Well-known side effects of clomid include - you guessed it - multiple births (aka twins, triplets...). For women using clomid, twins may occur in 5% of births. Triplets are much less frequent. Although there has been some discussion linking prescription infertility treatments like clomid to ovarian cancer, evidence seems to point now to other causes, even infertility itself as a cause of some cancers. There is no evidence that clomid causes an increase in congenital abnormalities or birth defects in children.

Clomiphene and Clomid Abuse. While clomid cannnot be "abused" in any traditional sense, it can be prescribed (or rather over-prescribed) for infertility issues before a fertility workup has been performed, or before there is even any sign of ovulatory disorder, anovulation, luteal phase defect (LPD), PCOS, etc. Proper screening is essential prior to prescription. Given that male fertility issues constitute nearly 30% of infertility cases, a thorough evaluation and/or fertility workup should be performed on the woman to verify that ovulation induction via clomid is indeed required. For women without ovulatory/ovulation issues or infertility symptoms, clomid use may actually interfere with conception. Before accepting a clomid prescription, ensure that your doctor has performed the requisite infertility workup and/or has correctly identified a fertility issue or ovulatory disorder.

Women with liver disease should not use clomid. Clomid should not be given to patients with ovarian cysts, since they may grow larger. It should not be taken by a patient who may be pregnant, although there is no proof of fetal problems or complications.

> Back to Infertility and Fertility Medications
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i got pregnant with my 3 year old boy with out taking n e medications after waiting 2 years to conceive but now dat he is bout to be 4 years old i want another kid but i cant get pregant cause i am very irregular with my menses so dr started me with provera is been 6 months now n finally gave me clomid i will start taking it this week on da 5th day of my menses i dont know if u guys can help but my quest is would it be easier for me to get pregnant with clomid since i dont have fertility problems its only dat i dont ovulate cause of irregularity Please help!!!

I'm 34, no birth control for over 8+yrs...regular periods every 27 days. Same partner 2yrs, semen analysis normal, HSG showed small fibroids but not large enough to prevent pregnancy. Starting my first round of clomid next week days 5-9. 50mg twice a day. I'm very nervous and anxious. I've heard both good and bad success stories about Clomid. Any advice is appreciated! My questions are:
What time of day should I take them?
Do I ovulate with regular periods?

let all those want babies not loose heart but be strong in faith.GOD is the greater life giver He give seed to the sower

My dr. told me that i've not been ovulating, i have been on clomid 5-9 days of my cycle and this is my 4th month on clomid, i believe and i'm trusting God that i wouldn't have anything to do with fertility drugs for it is not a good experience.
I pray that all that are expecting children, God grant us our heart desires in Jesus name AMEN!

I need God to help me i am devastated. I need a child of my own. I want to be called mummy. please encourage me

Im on my 2nd round of clomid at 100mg. My 1st round I took day 3-7 my period was 10 days late, I not sure if it was mental but I felt pregnant, nausea, sore breast, fatigue, cravings my Hubby was so excited pointing out all the symptoms but all test were negative went to the dr and she said it was a "chemical" Pregnancy! I was so discourage and now this cycle My hubby got called away to work and I im due to ovulate between 8th and 13th and we had intercourse everday until the 9th Sad Good Luck everyone !

Hi girls im amy, well i took clomid day 2-6, took ovulation tests cd8, 10, and 12 but never ovulated. i think it might have been because i mixed up my medication, i excidently took 50mg on cd2, 50mgcd3, 100mgcd4,150mgcd5, 150mgcd6 then 50mgcd7, my doctor never explained to me exactly what clomid was for the day he gave it to me, he just told me to take it from day 2 of my cycle, i have been having abdominal pains just undermy belly, just above my V'
and pains on my lower back, then just 3days ago ive been having sore a tender nipples, (very painful). While on clomid i had, blury vision (couldnt drive at all), i had horriable headachs and hotflashes. i am now in cd21, i really hope this works for is, i have been ttc with my fiance for a year now and ttc for 3years before meeting my fiance.

A new study from the Centers for Disease Control and Prevention (CDC) reports that Clomid (clomiphene citrate) has been found to be associated with an increased risk for 9 different types of birth defects. On November 26, 2010, the medical journal, "Human Reproduction," published online the results of the study on the popular fertility drug.

The implicated abnormalities included anencephaly (open cranium with absence of a brain), esophageal atresia (closed esophagus), omphalocele (protrusion of part of the intestine through the abdominal wall), craniosynostosis (premature fusion of the skull bones), 3 different types of heart defects and a defect of the brain (Dandy Walker malformation). The ninth defect (cloacal exstrophy) involves multiple defects of the gastrointestinal and genitourinary tracts.

After taking into account such factors as maternal age, history of prior miscarriages, smoking, use of alcohol and obesity, the epidemiologists found increased risks ranging from 60% for septal heart defects to 440% for cloacal exstrophy. Drawing on 8 years of data from the National Birth Defects Prevention Study, Dr. Jennita Reefhuis and her colleagues compared the drug’s exposure to 36 types of birth defects with those of 6,500 live born babies born without major birth anomalies, used as controls. No less than 22 of the remaining 27 birth defect categories likewise showed an increased risk, ranging from 10% up to 170% after exposure to Clomid, although the numbers were insufficient to reach the scientific standard for "statistical significance."

For anyone interested in more details about this study and the history of similar scientific studies involving Clomid and other fertility drugs, I would invite you to visit my website at

I will bless you with food and water and I will protect you from illness. There will be no miscarriages or infertility in your land, and I will give you long, full lives. (Exodus23:25,26 NLT)

HE gives the childless woman a family, making her a happy mother. Praise the LORD! (Psalm 113:9 NLT)
Anything is possible if a person believes (Mark 9:23 NLT)

As you wait on GOD, be content. HIS way is perfect, and HE brings a great REWARD for those who TRUST HIM. I pray that HE will encourage and strengthen you as you rest in HIM.

GOD is no respecter of persons. What he did for other women in the Bible he will do for you!

There is a Progesterone oil you can rub over your lower abdomen that will help with low progesterone before preg and during first trimester. Also, You can get clomid from your obgyn.. Hope this helps! Baby dust!

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By TTC veteran and mother of two, Elizabeth Andrews.