Clomid: How it Works and What to Expect

Is Clomid the Right Fertility Medication for Me? Clomid, Infertility and Ovulation Induction


Clomid (clomiphene, clomiphene citrate) is among the most well-know and frequently prescribed of all fertility drugs. Clomid is taken orally and is considered a "first line" prescription fertility drug for dealing with infertility issues. Clomid is so widely prescribed that you may even find a "Clomid Club" on many preconception forums and communities. Clomid is used predominately for inducing ovulation in women with ovulatory disorders like anovulation, PCOS, and other infertility symptoms.

Clomid works by impacting hormonal production, by influencing the "fertility hormones" (estrogen, FSH, and LH) that precipitate ovulation. Like many prescription medications, Clomid works by "tricking the brain" into believing that estrogen levels in the body are low. This in turn encourages the brain to send signals to release more Gonadotropin Releasing Hormone (GnRH), which causes the pituitary gland to produce more FSH (follicle stimulating hormone) and LH (luteinizing hormone). LH is the hormone that facilitates ovulation (the release of the egg), and it's also the hormone used as the marker in urine ovulation testing.

Sounds complicated? In effect, clomid precipitates, through these various hormonal mechanisms, increased production of LH and FSH, which in turn foster a mature ovarian follicle and the release of the ovum. This is called ovulation induction. In more clinical terms, Dr. G. Berger notes: "Structurally like estrogen, clomiphene binds to the sites in the brain where estrogen normally attaches, called estrogen receptors. Once these receptor sites are filled up with clomiphene, they can't bind with natural estrogen circulating in the blood and they are fooled into thinking that the amount of estrogen in the blood is too low. In response, the hypothalamus releases more GnRH, causing the pituitary to pump out more FSH, which then causes a follicle to grow to produce more estrogen and start maturing an egg to prepare for ovulation".

Clomid is taken orally for about five days near the beginning of the cycle. Dosage and "start dates" will be indicated by the prescribing doctor. Once ovulation commences, most pregnancies occur in the first 6 cycles of treatment. While clomid has a high rate of success in inducing ovulation, it cannot guarantee pregnancy. Note: if you test too early for ovulation in your cycle with a urine ovulation test (lh), you may receive a false positive on an ovulation test when using clomid.

Fertility Supplements and Clomid: Currently, there are a number of herbal-nutritional supplements on the market containing vitex (chasteberry, vitex agnus castus). These products may be viewed as an herbal infertility therapy, and products like FertilAid and FertilityBlend are based on impressive clinical studies indicating that fertility can be improved with fertility supplementation. However, both of these manufacturers indicate that clomid should not be used in conjunction with vitex (or herbal infertility products in general). Fertility supplements like Fertility Blend and FertilAid are non-prescription. While on clomid, women are still encouraged to take a prenatal supplement with folic acid.

Well-known side effects of clomid include - you guessed it - multiple births (aka twins, triplets...). For women using clomid, twins may occur in 5% of births. Triplets are much less frequent. Although there has been some discussion linking prescription infertility treatments like clomid to ovarian cancer, evidence seems to point now to other causes, even infertility itself as a cause of some cancers. There is no evidence that clomid causes an increase in congenital abnormalities or birth defects in children.

Clomiphene and Clomid Abuse. While clomid cannnot be "abused" in any traditional sense, it can be prescribed (or rather over-prescribed) for infertility issues before a fertility workup has been performed, or before there is even any sign of ovulatory disorder, anovulation, luteal phase defect (LPD), PCOS, etc. Proper screening is essential prior to prescription. Given that male fertility issues constitute nearly 30% of infertility cases, a thorough evaluation and/or fertility workup should be performed on the woman to verify that ovulation induction via clomid is indeed required. For women without ovulatory/ovulation issues or infertility symptoms, clomid use may actually interfere with conception. Before accepting a clomid prescription, ensure that your doctor has performed the requisite infertility workup and/or has correctly identified a fertility issue or ovulatory disorder.

Women with liver disease should not use clomid. Clomid should not be given to patients with ovarian cysts, since they may grow larger. It should not be taken by a patient who may be pregnant, although there is no proof of fetal problems or complications.

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Comments

Hello everyone...I was diagnosed with endometriosis in July and had laproscopic surgery in August..I started my 1st cycle of clomid (50mg) in October didn't ovulate..my 2nd cycle in November (100mg) and my doctor called me on yesterday and told me that I did indeed ovulate this time around, so I praying that we conceived this time...if my menustral cycle doesn't start by Dec. 12 she said it's a great chance that we did conceive...I'm 34 with no kids so I'm praying because my heart's greatest joy is becoming a mother...I will keep you posted...praying that everyone is blessed in the upcoming year with a healthy bundle of joy!

hello everyone ive been trying to get pg for 8yrs now in early may found out i was pg after getting off bcp and was in shock cause this was the first time ive gotten pg but bad news came across and lost the bby on mothers day Sad bby got stuck in my tube which was no way to save it so dr. said it was an ectopic pregnacy n had no choice but to go thru surgery which one of the option i wouldnt have pick so i cried my eyes out before preparing for surgery after surgery dr. said i was 5wks n 6days which i had no clue n also found out they removed my left tube now im dwn to one tube and just found out i have a small cyst on my right ovary but dr. said its not bad so now i went to go pay my gyn a visit n told him i would like to try to concieve but he said before doin that he wants me to go in for an HSG test which came out normal so he prescrbe me with 50 mg of clomid which i start today for 5days but i will kp u guys posted my fingers are crossed n prayn to god to blessed me with a beautiful healthy bby n sorry for the long paragraph bby dust to all may god blessed u Smile

hi all i was on my first round of clomid in october bcoz i dnt get ovulation so in november i got positive for pregnancy test thuo i m/c after 5week but i am now going to try again strait away.....gud luck to all d ttc

Well, I am on my first round of clomid and I am hoping to get pregnant when my husband comes home from Afghanistan for his R&R. So far everything seems to be going as the doctor says it would so I am hopeful. I was hoping to read about more success stories than I am reading on this sight. I is discouraging. I am so hopeful and excited all in one. Anyone that has a success story please post it for us first timers. Thanks

hi i have a baby girlof 4 years and i want to be pregent but i dont ovulate every month now am taking glomid it my first can i be pregent this month and this month i have ovulate i had taken my temperature it is hight and got a pain in lower

Hi ladies
I also PCOS and I know that it is hard to deal with. I to think about this condition alot. Sometime I even feel depress because I can't have kids naurally. I have find out that you can conceive with PCOS but need to keep tract of your ovulation days because people with PCOS don't ovulate every month. My husband is a great suppoter and he try to keep me positive about it so I want get depressed. I hope that God bless you all

Five years to trying to conceive with pcos. tried clomid didn't work. We split up & I fell pregnant naturally whilst on the pill (had only been with the guy 2mths hence why I was using the pill). Pcos is like a lottery. You can get pregnant & so likely will. Sadly it's a waiting game. Good luck x

After reading through the extract above alongside the above listed experiences, doubts of have reared up in my mind regarding clomid's usage.
I didn't undergo any tests but started using clomid upon the positive life experiences of my friends. It's my first cycle though but now am more confused and feel a bit guilty of self medication.
My first kid is 8 and i have had any since his birth. What to do now?

Well I'm on my second dose of clomid 50mg.I have a 9 yr old son from my ex but me and my current husband have been trying for 4 yrs. So I talked to my Dr and this us what he gave us. So hoping thus works. I'm not so sure as I never got pregant with 1st dose. Hoping it works this month as we are doing everything by the Dr order. Keeping my head up is hard but still praying it happens for us.

Hi
Its so comforting reading all this. Its so nice to know im not alone. My husband and i have been ttc for a year. im on my 2nd round of clomid. this time its 150mg. Im nervous about the s/e. I have always had a regular period and ovulation. our fert dr ran all our tests and my husbands sperm is on the low end and i have low ovarian reserve..(not too sure what that is...just its not good ). We are doing our 2nd iui next week. Im doing everything to make this happen but its so depressing and hard. Just wanted to thank you all for posting your stories....it really helps. god bless.

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