Clomid: How it Works and What to Expect

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Is Clomid the Right Fertility Medication for Me? Clomid, Infertility and Ovulation Induction

Clomid (clomiphene, clomiphene citrate) is among the most well-know and frequently prescribed of all fertility drugs. Clomid is taken orally and is considered a "first line" prescription fertility drug for dealing with infertility issues. Clomid is so widely prescribed that you may even find a "Clomid Club" on many preconception forums and communities. Clomid is used predominately for inducing ovulation in women with ovulatory disorders like anovulation, PCOS, and other infertility symptoms.

Clomid works by impacting hormonal production, by influencing the "fertility hormones" (estrogen, FSH, and LH) that precipitate ovulation. Like many prescription medications, Clomid works by "tricking the brain" into believing that estrogen levels in the body are low. This in turn encourages the brain to send signals to release more Gonadotropin Releasing Hormone (GnRH), which causes the pituitary gland to produce more FSH (follicle stimulating hormone) and LH (luteinizing hormone). LH is the hormone that facilitates ovulation (the release of the egg), and it's also the hormone used as the marker in urine ovulation testing.

Sounds complicated? In effect, clomid precipitates, through these various hormonal mechanisms, increased production of LH and FSH, which in turn foster a mature ovarian follicle and the release of the ovum. This is called ovulation induction. In more clinical terms, Dr. G. Berger notes: "Structurally like estrogen, clomiphene binds to the sites in the brain where estrogen normally attaches, called estrogen receptors. Once these receptor sites are filled up with clomiphene, they can't bind with natural estrogen circulating in the blood and they are fooled into thinking that the amount of estrogen in the blood is too low. In response, the hypothalamus releases more GnRH, causing the pituitary to pump out more FSH, which then causes a follicle to grow to produce more estrogen and start maturing an egg to prepare for ovulation".

Clomid is taken orally for about five days near the beginning of the cycle. Dosage and "start dates" will be indicated by the prescribing doctor. Once ovulation commences, most pregnancies occur in the first 6 cycles of treatment. While clomid has a high rate of success in inducing ovulation, it cannot guarantee pregnancy. Note: if you test too early for ovulation in your cycle with a urine ovulation test (lh), you may receive a false positive on an ovulation test when using clomid.

Fertility Supplements and Clomid: Currently, there are a number of herbal-nutritional supplements on the market containing vitex (chasteberry, vitex agnus castus). These products may be viewed as an herbal infertility therapy, and products like FertilAid and FertilityBlend are based on impressive clinical studies indicating that fertility can be improved with fertility supplementation. However, both of these manufacturers indicate that clomid should not be used in conjunction with vitex (or herbal infertility products in general). Fertility supplements like Fertility Blend and FertilAid are non-prescription. While on clomid, women are still encouraged to take a prenatal supplement with folic acid.

Well-known side effects of clomid include - you guessed it - multiple births (aka twins, triplets...). For women using clomid, twins may occur in 5% of births. Triplets are much less frequent. Although there has been some discussion linking prescription infertility treatments like clomid to ovarian cancer, evidence seems to point now to other causes, even infertility itself as a cause of some cancers. There is no evidence that clomid causes an increase in congenital abnormalities or birth defects in children.

Clomiphene and Clomid Abuse. While clomid cannnot be "abused" in any traditional sense, it can be prescribed (or rather over-prescribed) for infertility issues before a fertility workup has been performed, or before there is even any sign of ovulatory disorder, anovulation, luteal phase defect (LPD), PCOS, etc. Proper screening is essential prior to prescription. Given that male fertility issues constitute nearly 30% of infertility cases, a thorough evaluation and/or fertility workup should be performed on the woman to verify that ovulation induction via clomid is indeed required. For women without ovulatory/ovulation issues or infertility symptoms, clomid use may actually interfere with conception. Before accepting a clomid prescription, ensure that your doctor has performed the requisite infertility workup and/or has correctly identified a fertility issue or ovulatory disorder.

Women with liver disease should not use clomid. Clomid should not be given to patients with ovarian cysts, since they may grow larger. It should not be taken by a patient who may be pregnant, although there is no proof of fetal problems or complications.

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I am 33 and the proud mom of a 10 year old and a 3 year old. I have PCOS. So you know there is hope and clomid is great. Though I do not advocate a long time use of atkins because of the red meat and heart issues - I would tell you I have had problems with my period since I was 15. I was on a modified atkins (no white startch/ low carb/ no simple sugar) - and in the first month I had my period and I had it for 5 months straight by following this. This did not fix my non-ovulation problem but... I am going on clomid for the 3rd time and hope to be pregnant soon.

I'm thinking of trying clomid my concern is what side affect once getting pregnant. Will the clomid that I have taken effect the baby? Has anyone ever had a problem with their child after birtg? Exp: delayed development or any other issue... please I would like to know before going through this.

Hi m 24 Yrs old ,I was diagnose with pcos when I was 21yrs,I have been ttc over 3yrs m on my first round of clomid symptoms at all ,m going for blood test and scanning on Tuesday m nervous!baby dust to u all.

I have a three year old daughter we have been trying for another child for 12 months, 5months ago my period started to get very irregular nearly 7weeks apart, I feel I must have a fertility issue as I should be pregnant by now otherwise. Going to doc to get clomid perscribed. Any thing I should know or do first?

just started to take clomid...bit nervous..hope for good news

Hi I have Polycystic Ovaries therefore I dont get any periods.. has anyone been in my situation and got pregant on Colmid?

i had my first daughter 23 years ago and my son 19 years ago and my other daughter 18 years ago. im on my first cyclye of clomid i have no ferility problems just being 42 time is of the essence. no period yet waiting for find out.

I currently have a sixteen month old son thanks to 100 mg of clonid on my second round. I conceived again this past December on my second round again of the same dose but miscarried at ten weeks. We tried last month at the same dose but testing showed that I did not ovulate. So I got bumped to 150 mg day 3-7. Currently on CD 13 n no lh surge as of yet. We really want another and hope it works this time. I'm 36 and we don't want to run out of time. Also had a little more pain in lower back due to swelling, more concentrated on the right side.. but its worth it if we get another little one to hold.

Can i buy online desperate to conceive

Hi girls! I am 32 and I have only one working fallopian tube and concived at the fist cycle of Clomid! My baby now is 3,we a ttc again,and I am thinking go back to Clomid.Good luck to you all♥ I will pray for each of you!

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