Clomid: How it Works and What to Expect

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Is Clomid the Right Fertility Medication for Me? Clomid, Infertility and Ovulation Induction


Clomid (clomiphene, clomiphene citrate) is among the most well-know and frequently prescribed of all fertility drugs. Clomid is taken orally and is considered a "first line" prescription fertility drug for dealing with infertility issues. Clomid is so widely prescribed that you may even find a "Clomid Club" on many preconception forums and communities. Clomid is used predominately for inducing ovulation in women with ovulatory disorders like anovulation, PCOS, and other infertility symptoms.

Clomid works by impacting hormonal production, by influencing the "fertility hormones" (estrogen, FSH, and LH) that precipitate ovulation. Like many prescription medications, Clomid works by "tricking the brain" into believing that estrogen levels in the body are low. This in turn encourages the brain to send signals to release more Gonadotropin Releasing Hormone (GnRH), which causes the pituitary gland to produce more FSH (follicle stimulating hormone) and LH (luteinizing hormone). LH is the hormone that facilitates ovulation (the release of the egg), and it's also the hormone used as the marker in urine ovulation testing.

Sounds complicated? In effect, clomid precipitates, through these various hormonal mechanisms, increased production of LH and FSH, which in turn foster a mature ovarian follicle and the release of the ovum. This is called ovulation induction. In more clinical terms, Dr. G. Berger notes: "Structurally like estrogen, clomiphene binds to the sites in the brain where estrogen normally attaches, called estrogen receptors. Once these receptor sites are filled up with clomiphene, they can't bind with natural estrogen circulating in the blood and they are fooled into thinking that the amount of estrogen in the blood is too low. In response, the hypothalamus releases more GnRH, causing the pituitary to pump out more FSH, which then causes a follicle to grow to produce more estrogen and start maturing an egg to prepare for ovulation".

Clomid is taken orally for about five days near the beginning of the cycle. Dosage and "start dates" will be indicated by the prescribing doctor. Once ovulation commences, most pregnancies occur in the first 6 cycles of treatment. While clomid has a high rate of success in inducing ovulation, it cannot guarantee pregnancy. Note: if you test too early for ovulation in your cycle with a urine ovulation test (lh), you may receive a false positive on an ovulation test when using clomid.

Fertility Supplements and Clomid: Currently, there are a number of herbal-nutritional supplements on the market containing vitex (chasteberry, vitex agnus castus). These products may be viewed as an herbal infertility therapy, and products like FertilAid and FertilityBlend are based on impressive clinical studies indicating that fertility can be improved with fertility supplementation. However, both of these manufacturers indicate that clomid should not be used in conjunction with vitex (or herbal infertility products in general). Fertility supplements like Fertility Blend and FertilAid are non-prescription. While on clomid, women are still encouraged to take a prenatal supplement with folic acid.

Well-known side effects of clomid include - you guessed it - multiple births (aka twins, triplets...). For women using clomid, twins may occur in 5% of births. Triplets are much less frequent. Although there has been some discussion linking prescription infertility treatments like clomid to ovarian cancer, evidence seems to point now to other causes, even infertility itself as a cause of some cancers. There is no evidence that clomid causes an increase in congenital abnormalities or birth defects in children.

Clomiphene and Clomid Abuse. While clomid cannnot be "abused" in any traditional sense, it can be prescribed (or rather over-prescribed) for infertility issues before a fertility workup has been performed, or before there is even any sign of ovulatory disorder, anovulation, luteal phase defect (LPD), PCOS, etc. Proper screening is essential prior to prescription. Given that male fertility issues constitute nearly 30% of infertility cases, a thorough evaluation and/or fertility workup should be performed on the woman to verify that ovulation induction via clomid is indeed required. For women without ovulatory/ovulation issues or infertility symptoms, clomid use may actually interfere with conception. Before accepting a clomid prescription, ensure that your doctor has performed the requisite infertility workup and/or has correctly identified a fertility issue or ovulatory disorder.

Women with liver disease should not use clomid. Clomid should not be given to patients with ovarian cysts, since they may grow larger. It should not be taken by a patient who may be pregnant, although there is no proof of fetal problems or complications.

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Comments

My man & I been ttc for 6yrs and my dr just put me on Provera 10days which I'm done and I start clomid tomorrow. How do you know when your ovulating & when to start having intercourse? Some please help I'm new to all this. Thanks

My husband and I have been ttc for 5 months, and since he had a surgery when he was younger - I thought it may be affecting our chances. I was right. He was tested (twice) and the results have not been favorable - low count, low motility, low volume, and % normal sperm..you guessed it, low. My doctor wants to start me on Clomid to increase our chances with IUI. I start the clomid next month and we go in for IUI upon testing positive LH. has anyone dealt with this type of issue before?

for everyone who is scared. I was diagnosed with PCOS as a teenager and was told at the time that it would be difficult to get pregnant. I was prescribed Clomid and within a few months I was pregnant. I gave birth to a beautifull boy who is now 2 years. If your doctor has done his or her homework in your case don't be scared and Good luck!Smile

Have been trying for another baby for four years now after the birth of my son. He is now five and I've been taking clomid for approx six and a half months... My husband and I are just ecstatic since we are expecting twins as a result!!! Good luck to everyone!!!!!

I found out that I have PCOS when I was 19 and was told that I wouldn't be able to have children. I was devastated and couldn't accept that I would never be a mom. I decided to try despite what the doctors had told me and was prescribed clomid for 6 cycles. I became pregnant with the 5th round and gave birth to my daughter in Jan last year. I had no side effects and no complications with either the clomid or the pregnancy and I can't wait to try for my second baby. Whatever you do, don't give up on your dream to have a baby.

Okay I'm covncined. Let's put it to action.

I am 33 years old and have been tryin gto conceive for a year and a half. After going through routine bloodtests, an HSG and sonogram my docotr has prescibed Clomid. I'm a little nervous since many of the comments have stated miscarriages. Is this normal? I have never been pregnant and it scares me.

i misscarried 2 yrs ago at 8weeks,i found out 12 months ago that i have pcos, my dr has just given me clomid 50mg as i have never been on it befor i am alittle confused as to when i take it on tje box it says to take at days 2-6 does this mean day two of bleeding or day two.afyer.bleeding has stoped

my husband and i have been trying to concieve for about a year with NO luck..i have never been pregnant and my periods are irregular...i heard about clomid and have been thinking about talking to my doctor about it. is it helpful and does it really work? any advice would b greatly appreciated..thanks. n good luck to all of u.

Hi ladies. I too was so relieved to seen an updated converstation group on here! My husband and I have been ttc for about 4 years now and finally got the process started with the dr. I found out that I have a septated uterus and that I am not ovulating. Everyone in my family has children except for me. The dr started me on 50 mg of clomid. I actually don't start them until around the 23rd. But I am definitly holding out hope. If you have any inspirational advice let me know! Babydust to all

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